Treatment of the microfilaraemia of asymptomatic brugian filariasis with single doses of ivermectin, diethylcarbamazine or albendazole, in various combinations.
Identifieur interne : 00A956 ( Main/Exploration ); précédent : 00A955; suivant : 00A957Treatment of the microfilaraemia of asymptomatic brugian filariasis with single doses of ivermectin, diethylcarbamazine or albendazole, in various combinations.
Auteurs : R K Shenoy [Inde] ; S. Dalia ; A. John ; T K Suma ; V. KumaraswamiSource :
- Annals of tropical medicine and parasitology [ 0003-4983 ] ; 1999.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Albendazole (usage thérapeutique), Animaux, Association de médicaments, Brugia malayi, Calendrier d'administration des médicaments, Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Humains, Ivermectine (usage thérapeutique), Microfilaria, Mâle, Parasitémie (traitement médicamenteux), Résultat thérapeutique, Sujet âgé.
- MESH :
- traitement médicamenteux : Filariose lymphatique, Parasitémie.
- usage thérapeutique : Albendazole, Diéthylcarbamazine, Filaricides, Ivermectine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Association de médicaments, Brugia malayi, Calendrier d'administration des médicaments, Femelle, Humains, Microfilaria, Mâle, Résultat thérapeutique, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Albendazole (therapeutic use), Animals, Brugia malayi, Diethylcarbamazine (therapeutic use), Drug Administration Schedule, Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Female, Filaricides (therapeutic use), Humans, Ivermectin (therapeutic use), Male, Microfilariae, Middle Aged, Parasitemia (drug therapy), Treatment Outcome.
- MESH :
- chemical , therapeutic use : Albendazole, Diethylcarbamazine, Filaricides, Ivermectin.
- drug therapy : Elephantiasis, Filarial, Parasitemia.
- Adolescent, Adult, Aged, Animals, Brugia malayi, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Microfilariae, Middle Aged, Treatment Outcome.
Abstract
Several new chemotherapeutic tools are now available for the control of lymphatic filariasis. Combinations of single doses of antifilarial drugs are generally superior to single drugs. The efficacy and safety of albendazole in combination with diethylcarbamazine (DEC) or ivermectin, for the treatment of Brugia malayi infection, were investigated, for the first time, in an open, hospital-based study. Fifty-one asymptomatic microfilaraemics (with 108-4034 microfilariae/ml; median = 531) of both sexes and aged 14-70 years were randomly allocated to receive single-dose treatments of ivermectin (200 micrograms/kg) with diethylcarbamazine (DEC; 6 mg/kg), ivermectin (200 micrograms/kg) with albendazole (400 mg), DEC (6 mg/kg) with albendazole (400 mg), or albendazole (400 mg) alone. Albendazole alone had no effect on the microfilarial levels at the 1-year follow-up but both groups given DEC had significantly lower microfilaraemias (P < 0.015 and P < 0.02) than that given ivermectin with albendazole. Overall, 47%-64% of those given DEC but only 14% of those given ivermectin with albendazole appeared to be amicrofilaraemic 1 year post-treatment. The adverse reactions seen in the study were mild, transient and qualitatively similar to those seen earlier with ivermectin and DEC. The combination of DEC and albendazole, both well tested drugs, offers a new option for countries such as India where there is no onchocerciasis or loiasis and where ivermectin may not be immediately available. The direct and indirect effects of albendazole on intestinal helminths would be additional benefits.
PubMed: 10707109
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004B16
- to stream PubMed, to step Curation: 004B16
- to stream PubMed, to step Checkpoint: 004B16
- to stream Ncbi, to step Merge: 000281
- to stream Ncbi, to step Curation: 000281
- to stream Ncbi, to step Checkpoint: 000281
- to stream Main, to step Merge: 00AF15
- to stream Main, to step Curation: 00A956
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of the microfilaraemia of asymptomatic brugian filariasis with single doses of ivermectin, diethylcarbamazine or albendazole, in various combinations.</title><author><name sortKey="Shenoy, R K" sort="Shenoy, R K" uniqKey="Shenoy R" first="R K" last="Shenoy">R K Shenoy</name><affiliation wicri:level="1"><nlm:affiliation>Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha, India. rkshenoy@md3.vsnl.net.in</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha</wicri:regionArea><wicri:noRegion>Alappuzha</wicri:noRegion></affiliation></author><author><name sortKey="Dalia, S" sort="Dalia, S" uniqKey="Dalia S" first="S" last="Dalia">S. Dalia</name></author><author><name sortKey="John, A" sort="John, A" uniqKey="John A" first="A" last="John">A. John</name></author><author><name sortKey="Suma, T K" sort="Suma, T K" uniqKey="Suma T" first="T K" last="Suma">T K Suma</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10707109</idno><idno type="pmid">10707109</idno><idno type="wicri:Area/PubMed/Corpus">004B16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004B16</idno><idno type="wicri:Area/PubMed/Curation">004B16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004B16</idno><idno type="wicri:Area/PubMed/Checkpoint">004B16</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004B16</idno><idno type="wicri:Area/Ncbi/Merge">000281</idno><idno type="wicri:Area/Ncbi/Curation">000281</idno><idno type="wicri:Area/Ncbi/Checkpoint">000281</idno><idno type="wicri:doubleKey">0003-4983:1999:Shenoy R:treatment:of:the</idno><idno type="wicri:Area/Main/Merge">00AF15</idno><idno type="wicri:Area/Main/Curation">00A956</idno><idno type="wicri:Area/Main/Exploration">00A956</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment of the microfilaraemia of asymptomatic brugian filariasis with single doses of ivermectin, diethylcarbamazine or albendazole, in various combinations.</title><author><name sortKey="Shenoy, R K" sort="Shenoy, R K" uniqKey="Shenoy R" first="R K" last="Shenoy">R K Shenoy</name><affiliation wicri:level="1"><nlm:affiliation>Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha, India. rkshenoy@md3.vsnl.net.in</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Filariasis Chemotherapy Unit, T.D. Medical College Hospital, Alappuzha</wicri:regionArea><wicri:noRegion>Alappuzha</wicri:noRegion></affiliation></author><author><name sortKey="Dalia, S" sort="Dalia, S" uniqKey="Dalia S" first="S" last="Dalia">S. Dalia</name></author><author><name sortKey="John, A" sort="John, A" uniqKey="John A" first="A" last="John">A. John</name></author><author><name sortKey="Suma, T K" sort="Suma, T K" uniqKey="Suma T" first="T K" last="Suma">T K Suma</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author></analytic><series><title level="j">Annals of tropical medicine and parasitology</title><idno type="ISSN">0003-4983</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Albendazole (therapeutic use)</term><term>Animals</term><term>Brugia malayi</term><term>Diethylcarbamazine (therapeutic use)</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Ivermectin (therapeutic use)</term><term>Male</term><term>Microfilariae</term><term>Middle Aged</term><term>Parasitemia (drug therapy)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Albendazole (usage thérapeutique)</term><term>Animaux</term><term>Association de médicaments</term><term>Brugia malayi</term><term>Calendrier d'administration des médicaments</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Ivermectine (usage thérapeutique)</term><term>Microfilaria</term><term>Mâle</term><term>Parasitémie (traitement médicamenteux)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Albendazole</term><term>Diethylcarbamazine</term><term>Filaricides</term><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Parasitémie</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Albendazole</term><term>Diéthylcarbamazine</term><term>Filaricides</term><term>Ivermectine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Brugia malayi</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Microfilariae</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Association de médicaments</term><term>Brugia malayi</term><term>Calendrier d'administration des médicaments</term><term>Femelle</term><term>Humains</term><term>Microfilaria</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several new chemotherapeutic tools are now available for the control of lymphatic filariasis. Combinations of single doses of antifilarial drugs are generally superior to single drugs. The efficacy and safety of albendazole in combination with diethylcarbamazine (DEC) or ivermectin, for the treatment of Brugia malayi infection, were investigated, for the first time, in an open, hospital-based study. Fifty-one asymptomatic microfilaraemics (with 108-4034 microfilariae/ml; median = 531) of both sexes and aged 14-70 years were randomly allocated to receive single-dose treatments of ivermectin (200 micrograms/kg) with diethylcarbamazine (DEC; 6 mg/kg), ivermectin (200 micrograms/kg) with albendazole (400 mg), DEC (6 mg/kg) with albendazole (400 mg), or albendazole (400 mg) alone. Albendazole alone had no effect on the microfilarial levels at the 1-year follow-up but both groups given DEC had significantly lower microfilaraemias (P < 0.015 and P < 0.02) than that given ivermectin with albendazole. Overall, 47%-64% of those given DEC but only 14% of those given ivermectin with albendazole appeared to be amicrofilaraemic 1 year post-treatment. The adverse reactions seen in the study were mild, transient and qualitatively similar to those seen earlier with ivermectin and DEC. The combination of DEC and albendazole, both well tested drugs, offers a new option for countries such as India where there is no onchocerciasis or loiasis and where ivermectin may not be immediately available. The direct and indirect effects of albendazole on intestinal helminths would be additional benefits.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Dalia, S" sort="Dalia, S" uniqKey="Dalia S" first="S" last="Dalia">S. Dalia</name><name sortKey="John, A" sort="John, A" uniqKey="John A" first="A" last="John">A. John</name><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name><name sortKey="Suma, T K" sort="Suma, T K" uniqKey="Suma T" first="T K" last="Suma">T K Suma</name></noCountry><country name="Inde"><noRegion><name sortKey="Shenoy, R K" sort="Shenoy, R K" uniqKey="Shenoy R" first="R K" last="Shenoy">R K Shenoy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00A956 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00A956 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:10707109
|texte= Treatment of the microfilaraemia of asymptomatic brugian filariasis with single doses of ivermectin, diethylcarbamazine or albendazole, in various combinations.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:10707109" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |